NSD2 targeting reverses plasticity and drug resistance in prostate cancer

www.nature.com

NSD2 targeting reverses plasticity and drug resistance in prostate cancer

www.nature.com

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NatureEnglish · 2 days ago

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09727-z

Inhibition of the histone methyltransferase NSD2 and the androgen receptor in preclinical models can reverse lineage plasticity to suppress tumour growth and promote cell death in multiple subtypes of castration-resistant prostate cancer.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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