Adenosine signalling drives antidepressant actions of ketamine and ECT

www.nature.com

Adenosine signalling drives antidepressant actions of ketamine and ECT

www.nature.com

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NatureEnglish · 20 hours ago

Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09755-9

Adenosine signalling is identified as the central mechanism of action of the antidepressant effects of ketamine and electroconvulsive therapy, and newly developed analogues of ketamine exhibit improved antidepressant efficacy with reduced side effects.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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