Anti-progestin therapy targets hallmarks of breast cancer risk

www.nature.com

Anti-progestin therapy targets hallmarks of breast cancer risk

www.nature.com

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NatureEnglish · 21 hours ago

Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09684-7

Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing epithelial–stromal remodelling and suppression of luminal progenitors.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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