Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology

www.nature.com

Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology

www.nature.com

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NatureEnglish · 1 day ago

Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09698-1

Synthetic fibril strain 1B is a pathogen that is capable of self-replication and inducing glial cytoplasmic inclusions in vivo in mice, and the structural features of 1B may underlie the pathology of individuals with multiple-system atrophy.

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