Targeting FSP1 triggers ferroptosis in lung cancer

www.nature.com

Targeting FSP1 triggers ferroptosis in lung cancer

www.nature.com

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NatureEnglish · 2 days ago

Nature, Published online: 05 November 2025; doi:10.1038/s41586-025-09710-8

The ferroptosis suppressor protein FSP1 has a critical role in ferroptosis protection of tumours across multiple in vivo models and is linked to worse prognosis in human lung adenocarcinoma, suggesting its potential as a therapeutic target in lung cancer.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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