SIGLEC12 mediates plasma membrane rupture during necroptotic cell death

www.nature.com

SIGLEC12 mediates plasma membrane rupture during necroptotic cell death

www.nature.com

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NatureEnglish · 4 hours ago

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09741-1

CRISPR–Cas9-based genome-wide screening shows that SIGLEC12 mediates plasma membrane rupture in cells undergoing necroptosis, possibly through a human-specific mechanism, indicating its potential as a therapeutic target.

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