Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy

www.nature.com

Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy

www.nature.com

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NatureEnglish · 5 days ago

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09745-x

Acetyl-coenzyme A functions as a non-canonical signal to trigger mitophagy, and the acetyl-coenzyme A–NLRX1 axis underlies the KRAS-inhibitor-induced mitophagy response and promotes drug resistance, providing a metabolic mechanism of KRAS inhibitor resistance.

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