Synthesis of enantioenriched atropisomers by biocatalytic deracemization

www.nature.com

Synthesis of enantioenriched atropisomers by biocatalytic deracemization

www.nature.com

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NatureEnglish · 3 days ago

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09738-w

A new method for deracemization of atropisomers is described which leverages a P450 enzyme-mediated process involving bond rotation for enantioenrichment.

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