Spatial fibroblast niches define Crohn’s fistulae

www.nature.com

Spatial fibroblast niches define Crohn’s fistulae

www.nature.com

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NatureEnglish · 11 hours ago

Nature, Published online: 12 November 2025; doi:10.1038/s41586-025-09744-y

Spatial transcriptomic analysis of cells in intestinal fistulae of patients with Crohn’s disease reveals the existence of specialized fistula-associated cell states with distinct signalling profiles and extracellular matrix architecture.

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