While microplastic pollution continues to advance, research into its possible effects on health remains hampered by technical hurdles. To date, there are no suitable methods for precisely identifying the particles in the body without destroying tissue. As part of two research projects, a team of scientists from MedUni Vienna, together with partner institutions, has now established a new method that locates microplastics in tissue in a non-destructive and spatially resolved manner—i.e., in such a way that the exact location of the particles within the intact tissue structure remains visible.