Hepatic zonation determines tumorigenic potential of mutant β-catenin

www.nature.com

Hepatic zonation determines tumorigenic potential of mutant β-catenin

www.nature.com

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NatureEnglish · 4 days ago

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09733-1

Zonal positioning in the liver determines whether the CTNNB1 oncogene can induce liver cancer.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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