Structural basis of regulated N-glycosylation at the secretory translocon

www.nature.com

Structural basis of regulated N-glycosylation at the secretory translocon

www.nature.com

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NatureEnglish · 4 days ago

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09756-8

The structural mechanism of a natively isolated GRP94 folding intermediate tethered to a CCDC134-bound translocon is described, revealing how the nascent chain remodels the translocon to control N-glycosylation by OST.

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