Semantic design of functional de novo genes from a genomic language model

www.nature.com

Semantic design of functional de novo genes from a genomic language model

www.nature.com

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NatureEnglish · 4 days ago

Nature, Published online: 19 November 2025; doi:10.1038/s41586-025-09749-7

By learning a semantics of gene function based on genomic context, the genomic language model Evo autocompletes DNA prompts to generate novel genes encoding protein and RNA molecules with defined activities, whose sequences generalize beyond those found in nature.

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