J Adv Res. 2025 Nov 20:S2090-1232(25)00911-7. doi: 10.1016/j.jare.2025.11.016. Online ahead of print.

ABSTRACT

BACKGROUND: Testosterone is a crucial sex hormone that plays an important role in physiology. In recent decades, dietary compounds have demonstrated the ability to modulate testosterone levels in the body. Moreover, clinical studies have identified variations in testosterone levels among individuals with distinct dietary patterns.

AIM OF REVIEW: This study systematically evaluates the effects of four prevalent dietary patterns on testosterone: the ketogenic, vegetarian, mediterranean and western diet. The primary objective is to investigate the mechanisms through which both macronutrient patterns and key micronutrients testosterone homeostasis. This analysis aims to establish an evidence-based foundation for nutritional approaches to testosterone optimization.

KEY SCIENTIFIC CONCEPTS OF REVIEW: Ketogenic diets may enhance testosterone synthesis through increased cholesterol availability, a key precursor, while reducing TNF-α and IL-6. Elevated ketone bodies can suppress both neuropeptide Y release and gastric hunger peptide. Vegetarian diets, conversely, frequently result in reduced cholesterol bioavailability owing to high fiber content and low fat intake, which may consequently impair testosterone synthesis. Nevertheless, their abundant antioxidants counteract oxidative stress, thereby supporting male reproductive health. Mediterranean diets enhance testosterone synthesis via synergistic actions of multiple bioactive nutrients within this dietary pattern. Oleocanthal inhibits COX-1 and COX-2 enzyme activity, while resveratrol reduce NO production, ROS levels, and LDL cholesterol. Additionally, olive oil enhances testicular antioxidant capacity and restore the SREBP2 cholesterol pathway. Western diets, characterized by excessive fat and sugar intake, promote obesity-associated testosterone decline through hepcidin overproduction, which disrupts iron homeostasis and testicular function. Furthermore, excess adipose tissue can increases production of TNF-α, IL-6, leptin, and NEFA, while cholesterol overload may trigger endoplasmic reticulum stress in testicular cells. For individuals with dysregulated androgen levels, targeted dietary modifications are advised as adjunctive therapy to help restore hormone balance.

PMID:41274640 | DOI:10.1016/j.jare.2025.11.016

From ketogenic via this RSS feed