Inhibitory PD-1 axis maintains high-avidity stem-like CD8+ T cells

www.nature.com

Inhibitory PD-1 axis maintains high-avidity stem-like CD8+ T cells

www.nature.com

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NatureEnglish · 2 days ago

Nature, Published online: 26 November 2025; doi:10.1038/s41586-025-09440-x

PD-1 blockade interferes with the selective expansion and maintenance of high-affinity TCR stem-like clones that have a critical role in effective checkpoint blockade therapy.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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