When a cell receives a message from outside, it generates a molecule called cyclic AMP (cAMP) to relay this message. To ensure the signal reaches the correct effector without triggering pathways accidentally, cAMP levels must be maintained around their point of origin and at the right level. ABCC4, a protein that transports cAMP out of cells and also contributes to drug resistance, helps with this local control. Yet, how ABCC4 is held in place at the right spot to perform these functions was not clear.