Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency

www.nature.com

Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency

www.nature.com

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NatureEnglish · 2 days ago

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09821-2

A forward genetic screen in Caenorhabditis elegans reveals that decreased levels of the ferredoxin FDX2 suppress the loss of frataxin in worms and in mice by relief of FDX2 inhibition of frataxin-stimulated NFS1 activity.

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