Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity

www.nature.com

Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity

www.nature.com

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NatureEnglish · 3 days ago

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09828-9

The ALPK1 agonist UDSP-Hep stimulates tumour-cell antigen presentation, macrophage–DC cross-priming and differentiation of protective memory T cells.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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