Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma

www.nature.com

Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma

www.nature.com

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NatureEnglish · 10 hours ago

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09825-y

Lung adenocarcinomas bearing the ID2 mutational signature display increased LINE-1 retrotransposon activity, which contributes to their fast evolutionary dynamics and aggressive phenotype.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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