Cross-regulation of [2Fe–2S] cluster synthesis by ferredoxin-2 and frataxin

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Cross-regulation of [2Fe–2S] cluster synthesis by ferredoxin-2 and frataxin

www.nature.com

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NatureEnglish · 2 days ago

Nature, Published online: 10 December 2025; doi:10.1038/s41586-025-09822-1

A finely balanced ratio of ferredoxin-2 (FDX2) and frataxin (FXN) is essential for the synthesis of iron–sulfur clusters, and interventions targeting this ratio could provide a way to treat related diseases, such as Friedreich’s ataxia.

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