Dogma-defying signalling through G proteins could lead to better pain relief

www.nature.com

Dogma-defying signalling through G proteins could lead to better pain relief

www.nature.com

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NatureEnglish · 4 days ago

Nature, Published online: 18 December 2025; doi:10.1038/d41586-025-03810-1

Unexpected behaviours in G proteins could be exploited to design next-generation opioid drugs that provide stronger, longer-lasting pain relief.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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