Managing GLUT 1 Deficiency with the Ketogenic Diet: A Retrospective Look at Seizures, Medications, and Side Effects in a Pediatric Cohort - PubMed
pubmed.ncbi.nlm.nih.gov
Glucose transporter type 1 deficiency syndrome (GLUT1DS) is a genetic condition associated with complex neurologic symptoms, including epilepsy. Ketogenic diet therapy (KDT) is considered the standard treatment for GLUT1DS. This retrospective study identified trends in treatment with KDT for patient …

J Child Neurol. 2026 Jan 9:8830738251409560. doi: 10.1177/08830738251409560. Online ahead of print.

ABSTRACT

Glucose transporter type 1 deficiency syndrome (GLUT1DS) is a genetic condition associated with complex neurologic symptoms, including epilepsy. Ketogenic diet therapy (KDT) is considered the standard treatment for GLUT1DS. This retrospective study identified trends in treatment with KDT for patients with GLUT1DS to optimize the current standards of care.MethodsA retrospective chart review was performed to identify patients at a pediatric institution with GLUT1DS receiving the ketogenic diet.ResultsTwelve patients were identified; 10 met inclusion criteria. A classic ketogenic diet (cKD) with a 3:1 ratio provides effective support for patients in this sample.ConclusionResults of the study suggest that a 3:1 ratio of KDT, which may increase tolerance and adherence and reduce adverse effects, may be acceptable in patients with GLUT1DS.

PMID:41512108 | DOI:10.1177/08830738251409560

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