Brain Dev. 2026 Jan 16;48(1):104500. doi: 10.1016/j.braindev.2026.104500. Online ahead of print.

ABSTRACT

OBJECTIVE: This study aims to investigate research trends, key contributors, and emerging topics in the field of infantile epileptic spasms syndrome (IESS).

METHODS: Publications on IESS from 1954 to 2024 were retrieved from the Web of Science Core Collection (WoSCC) database. Bibliometric analysis was performed using Microsoft Excel, VOSviewer, CiteSpace, and R version 4.3.3.

RESULTS: A total of 2905 publications were identified, revealing a marked increase in research output from 2000 onward. The USA led with 760 publications. The University of California System was the most productive institution, contributing 420 papers. Epilepsia was the most influential journal, publishing 371 papers with 12,246 citations. Leading authors included Naomichi Matsumoto and Ingrid E. Scheffer. Keywords formed five thematic clusters: (1) genetic foundations and molecular mechanisms (e.g., “mutations”), (2) therapeutic strategies for seizure control (e.g., “ketogenic diet”), (3) epidemiological patterns and seizure classification (e.g., “classification”), (4) clinical practices and treatment outcomes (e.g., “vigabatrin”), and (5) brain structure and diagnostic imaging (e.g., “MRI”). Burst keyword analysis indicated a focus on terms including “encephalopathy”, “epileptic spasms”, “intellectual disability”, “ilae commission”, “hypsarrhythmia”, “classification”, “multicenter”, and “management”.

CONCLUSION: The findings highlight current hotspots spanning genetic mechanisms, therapeutic strategies, epidemiological patterns, clinical practices, and neuroimaging. Future research should optimize treatments, improve diagnostics, and address developmental impacts.

PMID:41546957 | DOI:10.1016/j.braindev.2026.104500

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