Fibroblastic reticular cells direct the initiation of T cell responses via CD44

www.nature.com

Fibroblastic reticular cells direct the initiation of T cell responses via CD44

www.nature.com

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NatureEnglish · 12 hours ago

Nature, Published online: 21 January 2026; doi:10.1038/s41586-025-09988-8

CD44 expressed by fibroblastic reticular cells in secondary lymphoid organs regulates trafficking of dendritic cells, and thus has an essential role in the priming of T cells and the adaptive immune response.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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