Critical role for a high-plasticity cell state in lung cancer

www.nature.com

Critical role for a high-plasticity cell state in lung cancer

www.nature.com

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NatureEnglish · 1 day ago

Nature, Published online: 21 January 2026; doi:10.1038/s41586-025-09985-x

The high-plasticity cell state (HPCS) is a critical hub that enables reciprocal transitions between cancer cell states, and targeting the HPCS may suppress cancer progression and eradicate treatment resistance.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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