Identification of an allosteric site on the E3 ligase adapter cereblon

www.nature.com

Identification of an allosteric site on the E3 ligase adapter cereblon

www.nature.com

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NatureEnglish · 2 months ago

Nature, Published online: 21 January 2026; doi:10.1038/s41586-025-09994-w

An allosteric site on the E3 ligase adapter cereblon can be targeted to modulate the efficacy of cereblon in targeted protein degradation applications.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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