Metabolic diseases such as obesity, fatty liver, and insulin resistance are rapidly increasing worldwide, but fundamental methods to regulate the process of fat formation remain limited. In particular, once adipocytes (fat cells) are formed, they are difficult to reduce, making treatment challenging. A research team from KAIST has discovered the existence of a switch that prevents fat formation. This discovery elucidates how an epigenetic switch, which regulates gene activity without altering the DNA sequence itself, functions during the process of adipogenesis, presenting new possibilities for the precise control of obesity and metabolic diseases in the future.