Nature, Published online: 28 January 2026; doi:10.1038/d41586-025-04012-5

Recapitulating the complexity of human organs in vitro would accelerate drug discovery and enable personalized treatments. By combining different types of liver cell from donor tissues, in vitro models of a liver region that mirror some of the organ’s main structures and functions can be assembled, getting closer to reproducing mini livers in vitro.

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