Structure and mechanism of the human bile acid transporter OSTα–OSTβ

www.nature.com

Structure and mechanism of the human bile acid transporter OSTα–OSTβ

www.nature.com

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NatureEnglish · 2 months ago

Nature, Published online: 28 January 2026; doi:10.1038/s41586-025-09934-8

Cryo-electron microscopy structures of the bile acid transporter OSTα–OSTβ, which has a key role in bile acid homeostasis, provide insight into its distinct architecture and mechanism of substrate translocation.

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