Regulation of STING activation by phosphoinositide and cholesterol

www.nature.com

Regulation of STING activation by phosphoinositide and cholesterol

www.nature.com

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NatureEnglish · 19 days ago

Nature, Published online: 04 February 2026; doi:10.1038/s41586-025-10076-0

Phosphatidylinositol phosphates together with cholesterol bind at the interface between STING dimers, directly promoting high-order oligomerization.

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