ZFTA–RELA ependymomas make itaconate to epigenetically drive fusion expression

www.nature.com

ZFTA–RELA ependymomas make itaconate to epigenetically drive fusion expression

www.nature.com

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NatureEnglish · 24 days ago

Nature, Published online: 04 February 2026; doi:10.1038/s41586-025-10005-1

The ZFTA–RELA fusion, an oncogene for ependymomas, promotes the production of itaconate, and its dependence on this metabolite represents a new therapeutic target for this cancer.

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