Nucleotide signals coordinate activation and inhibition of bacterial immunity

www.nature.com

Nucleotide signals coordinate activation and inhibition of bacterial immunity

www.nature.com

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NatureEnglish · 9 days ago

Nature, Published online: 18 February 2026; doi:10.1038/s41586-026-10135-0

Biochemical and structural studies show that the bacterial dGTPase CloA is activated by virally produced dTTP and inhibited by 5′-triphosphothymidyl-3′5′-thymidine produced by its regulatory partner CloB, and thereby balances antiviral defence and immune-mediated toxicity.

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