Nature, Published online: 18 February 2026; doi:10.1038/s41586-026-10160-z

MASH is driven by the secreted GPNMB ectodomain, which binds hepatocyte RYK to activate ERK1/2 and promote lipid uptake and lipogenic programs; blocking the GPNMB–RYK axis prevented and treated MASH in preclinical models.

From Nature via this RSS feed