Nature, Published online: 18 February 2026; doi:10.1038/s41586-026-10153-y

Cryo-electron microscopy suggests a model in which microtubules, rather than adaptors in the cytoplasm, act as the primary platform for dynein–dynactin assembly, while LIS1 stabilizes low-microtubule-affinity intermediates near the pre-assembled complexes.

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