Reduced cyclin D3 expression in erythroid cells protects against malaria

www.nature.com

Reduced cyclin D3 expression in erythroid cells protects against malaria

www.nature.com

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NatureEnglish · 15 days ago

Nature, Published online: 18 February 2026; doi:10.1038/s41586-026-10110-9

Population-level analyses and in vitro experiments show that a specific genetic variant of cyclin D3 inhibits the growth of the malaria-causing parasite Plasmodium falciparum in erythrocytes, and suggest that its high frequency in Sardinia was driven by past endemic malaria.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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