Mol Neurobiol. 2026 Feb 19;63(1):460. doi: 10.1007/s12035-026-05751-w.
ABSTRACT
Schizophrenia (SCZ), a chronic and debilitating mental disorder affecting approximately 1% of the global population, involves complex interactions among genetic, environmental, and lifestyle factors, including diet and stress. Current pharmacological treatments focus primarily on symptom alleviation, with clozapine recognized as the most effective antipsychotic for resistant patients. However, emerging evidence underscores the importance of nutritional interventions and lifestyle modifications in managing mental health disorders, including SCZ. Recent advances in nutritional psychiatry highlight the influence of dietary patterns, nutrient intake, and the gut microbiota on brain function and mental health. Dysbiosis, characterized by altered gut microbiota composition, has been linked to neuroinflammation, neurotransmitter imbalances, and impaired neurodevelopment, all of which are pertinent to SCZ pathophysiology. Notably, maternal nutrition during pregnancy and early life significantly impacts fetal neurodevelopment and may predispose offspring to SCZ via epigenetic mechanisms. Furthermore, dietary habits, particularly high consumption of fast food and processed carbohydrates, are prevalent among individuals with SCZ, exacerbating nutritional deficiencies and gut microbiota dysregulation. The gut-brain axis mediates these interactions through neural, endocrine, and immune pathways, influencing neurotransmitter synthesis and brain function. Interventions such as ketogenic diets, probiotics, prebiotics, and natural antioxidants are under investigation for their potential to modulate microbiota composition and ameliorate SCZ symptoms. This comprehensive review focuses on the current literature on the microbiota-gut-brain axis, nutritional strategies, and their therapeutic implications, offering a framework for integrating nutritional management into SCZ care to improve clinical outcomes and overall health.
PMID:41712175 | DOI:10.1007/s12035-026-05751-w
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