Convergent MurJ flippase inhibition by phage lysis proteins

www.nature.com

Convergent MurJ flippase inhibition by phage lysis proteins

www.nature.com

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NatureEnglish · 2 days ago

Nature, Published online: 25 February 2026; doi:10.1038/s41586-026-10163-w

A common mechanism of inhibition of the essential lipid II flippase MurJ by three distinct phage-encoded single-gene lysis proteins provides insights into potential new targets for antimicrobial development.

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