A membrane-bound nuclease directly cleaves phage DNA during genome injection

www.nature.com

A membrane-bound nuclease directly cleaves phage DNA during genome injection

www.nature.com

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NatureEnglish · 3 days ago

Nature, Published online: 25 February 2026; doi:10.1038/s41586-026-10207-1

A widespread bacterial defence system called SNIPE is shown to localize to the cell membrane, where it identifies and cleaves the DNA of infecting phage as it is injected into the bacterial cell.

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