Exapted CRISPR–Cas12f homologues drive RNA-guided transcription

www.nature.com

Exapted CRISPR–Cas12f homologues drive RNA-guided transcription

www.nature.com

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NatureEnglish · 7 days ago

Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10166-7

Specialized σ factors interact with nuclease-dead, CRISPR–Cas12f proteins to form potent, RNA-guided gene activation systems that function independently of fixed promoter motifs.

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