The molecular basis of force selectivity by PIEZO2

www.nature.com

The molecular basis of force selectivity by PIEZO2

www.nature.com

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NatureEnglish · 9 days ago

Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10182-7

PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.

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