A metabolic alarmin from keratinocytes potentiates systemic humoral immunity

www.nature.com

A metabolic alarmin from keratinocytes potentiates systemic humoral immunity

www.nature.com

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NatureEnglish · 24 hours ago

Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10167-6

Farnesyl pyrophosphate—a mevalonate pathway metabolic intermediate—is an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and CCL20.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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