Ageing promotes metastasis via activation of the integrated stress response

www.nature.com

Ageing promotes metastasis via activation of the integrated stress response

www.nature.com

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NatureEnglish · 16 days ago

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10216-0

Ageing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrated stress response, and a therapeutic opportunity in older patients is revealed.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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