Facile induction of immune tolerance by an interleukin-2–TGFβ surrogate agonist

www.nature.com

Facile induction of immune tolerance by an interleukin-2–TGFβ surrogate agonist

www.nature.com

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NatureEnglish · 6 days ago

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10208-0

A fusion protein designed to comprise IL-2 and a helminth-derived TGFβ mimic activates IL-2 and TGFβ signalling pathways in IL-2 receptor-expressing T cells and induces stable antigen-specific regulatory T cells in peripheral lymphoid organs.

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