Capturing dynamic phage–pathogen coevolution by clinical surveillance

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Capturing dynamic phage–pathogen coevolution by clinical surveillance

www.nature.com

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NatureEnglish · 4 days ago

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10136-z

The acquisition of a parasitic anti-phage mobile genetic element, PLE11, showing potent anti-phage activity against cocirculating ICP1, and the subsequent evolution of ICP1 to escape this defense, are captured, revealing the molecular basis of the natural selection of a globally notable pathogen and its virus.

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