The dynamic basis of G-protein recognition and activation by a GPCR

www.nature.com

The dynamic basis of G-protein recognition and activation by a GPCR

www.nature.com

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NatureEnglish · 7 days ago

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10228-w

Conventional and time-resolved cryo-electron microscopy reveal how NTSR1 dynamically engages and releases different G proteins, capturing over 20 intermediates and uncovering key mechanistic steps in GDP- and GTP-driven activation, subtype selectivity and distinct dissociation pathways.

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