Adaptive evolution of gene regulatory networks in mammalian neocortex

www.nature.com

Adaptive evolution of gene regulatory networks in mammalian neocortex

www.nature.com

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NatureEnglish · 12 days ago

Nature, Published online: 18 March 2026; doi:10.1038/s41586-026-10226-y

The excitatory neuron diversity and specialized connectivity of complex, multilayered mammalian neocortex are driven by mammalian-specific cis-regulatory elements bound by ZBTB18, deletion of which disrupts gene expression and results in projection patterns resembling those of non-mammalian brains.

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