High levels of circular DNA made as immune cells develop increases the risk of leukaemia relapse

www.nature.com

High levels of circular DNA made as immune cells develop increases the risk of leukaemia relapse

www.nature.com

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NatureEnglish · 1 month ago

Nature, Published online: 06 August 2025; doi:10.1038/d41586-025-02421-0

DNA segments that are naturally excised during immune-cell development can replicate, drive damage at various genomic sites and lead to cancer recurrence.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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