Structural basis of supercoiling-induced CRISPR–Cas9 off-target activity

www.nature.com

Structural basis of supercoiling-induced CRISPR–Cas9 off-target activity

www.nature.com

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NatureEnglish · 5 days ago

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10255-7

Cas9 structures explain topology sensing and off-target activation.

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Nature is a weekly international journal publishing the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

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