Structural energetics of cold sensitivity

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Structural energetics of cold sensitivity

www.nature.com

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NatureEnglish · 7 days ago

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10276-2

Data from cryogenic electron microscopy combined with hydrogen–deuterium exchange mass spectrometry inform a mechanism for cold-evoked activation of the TRPM8 channel, providing a structural and energetic framework to explain cold sensitivity.

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