A µ-opioid receptor superagonist analgesic with minimal adverse effects

www.nature.com

A µ-opioid receptor superagonist analgesic with minimal adverse effects

www.nature.com

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NatureEnglish · 9 days ago

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10299-9

N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.

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